The chromatin landscape of healthy and injured cell types in the human kidney

Abstract excerpt

There is a need to define regions of gene activation or repression that control human kidney cells in states of health, injury, and repair to understand the molecular pathogenesis of kidney disease and design therapeutic strategies. However, comprehensive integration of gene expression with epigenetic features that define regulatory elements remains a significant challenge. We measured dual single nucleus RNA expr...

Topics

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• Epigenomics
• Hepatocyte Nuclear Factor 4
• Nephrons
• Organogenesis
• Podocytes
• Renal Insufficiency, Chronic
• RNA-Seq
• Transcription Factor AP-2

Identifiers and source

Literature Corpus work

168ca24e-11f8-51ea-84ff-ecaa24be3cf9

DOI

10.1101/2023.06.07.543965