Article
Single cell resolution regulatory landscape of the mouse kidney highlights cellular differentiation programs and renal disease targets
2020-05-26
Abstract excerpt
Determining the epigenetic program that generates unique cell types in the kidney is critical for understanding cell-type heterogeneity during tissue homeostasis and injury response. Here, we profiled open chromatin and gene expression in developing and adult mouse kidneys at single cell resolution. We show critical reliance of gene expression on distal regulatory elements (enhancers). We define key cell type-spec...
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Identifiers and source
- Literature Corpus work
- 310d52ac-097a-55dc-a481-86e7d51b5869
- DOI
- 10.1101/2020.05.24.113910