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Article

Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function.

Nature genetics - 1 Oct 2024

Loeb Gabriel B, Kathail Pooja, Shuai Richard W, Chung Ryan, Grona Reinier J, Peddada Sailaja, Sevim Volkan, Federman Scot, Mader Karl, Chu Audrey Y, Davitte Jonathan, Du Juan, Gupta Alexander R, Ye Chun Jimmie, Shafer Shawn, Przybyla Laralynne, Rapiteanu Radu, Ioannidis Nilah M, Reiter Jeremy F

Abstract excerpt

Kidney failure, the decrease of kidney function below a threshold necessary to support life, is a major cause of morbidity and mortality. We performed a genome-wide association study (GWAS) of 406,504 individuals in the UK Biobank, identifying 430 loci affecting kidney function in middle-aged adults. To investigate the cell types affected by these loci, we integrated the GWAS with human kidney candidate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

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Share to Regulatory Sequences, Nucleic Acid

Source

Identifiers

PMID: 39256582
DOI: 10.1038/s41588-024-01904-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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