Article

Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function

2024-06-22

Abstract excerpt

Kidney disease is highly heritable; however, the causal genetic variants, the cell types in which these variants function, and the molecular mechanisms underlying kidney disease remain largely unknown. To identify genetic loci affecting kidney function, we performed a GWAS using multiple kidney function biomarkers and identified 462 loci. To begin to investigate how these loci affect kidney function, we generated...

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Literature Corpus work: 31be8af3-5d3a-5d69-b947-e651f64b3661
DOI: 10.1101/2024.06.18.599625

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