Article

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

2020-11-10

Abstract excerpt

The functional interpretation of GWAS remains challenging due to cell-type dependent influences of genetic variants. Here, we generated comprehensive maps of expression quantitative trait loci (eQTL) for 659 microdissected human kidney samples and identified cell-type eQTLs by mapping interactions between cell type abundance and genotype. Separately, we generated single cell open chromatin maps (by snATAC-seq) for...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7c9f8798-e361-51e3-addf-d38142633072
DOI: 10.1101/2020.11.09.375592

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatmentsDOI 10.1101/2020.11.09.375592Read

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments.Semantic proximity Read

Unravelling the complex genetics of common kidney diseases: from variants to mechanisms.Semantic proximity Read

Integration of GWAS Summary Statistics and Gene Expression Reveals Target Cell Types Underlying Kidney Function TraitsSemantic proximity Read

Chromatin architecture reveals cell type-specific target genes for kidney disease risk variantsSemantic proximity Read

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.Semantic proximity Read

Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney functionSemantic proximity Read

Mapping kidney trait heritability to individual cells reveals disease-specific remodeling of genetic risk architectureSemantic proximity Read

Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications.Semantic proximity Read

Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.Semantic proximity Read

Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function.Semantic proximity Read

A reference tissue atlas for the human kidneySemantic proximity Read

Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLsSemantic proximity Read