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A single-cell multiomic analysis of kidney organoid differentiation

8 May 2023

Abstract excerpt

Kidney organoids differentiated from pluripotent stem cells are powerful models of kidney development and disease but are characterized by cell immaturity and off-target cell fates. Comparing the cell-specific gene regulatory landscape during organoid differentiation with human adult kidney can serve to benchmark progress in differentiation at the epigenome and transcriptome level for individual organoid cell...

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PMID: 37155865
DOI: 10.1073/pnas.2219699120

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