Integrated Functional Genomic Analysis Enables Annotation of Kidney Genome-Wide Association Study Loci

Abstract excerpt

Significance Statement The absence of high-resolution epigenomic maps of key kidney cell types has hampered understanding of kidney-specific genome regulation in health and disease. Kidney-associated genetic variants, identified in genome-wide association studies, are concentrated in accessible chromatin regions containing regulatory DNA elements. The authors describe the generation and initial characterization...

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