Article
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments.
Nature genetics - 1 Sept 2021
Sheng Xin, Guan Yuting, Ma Ziyuan, Wu Junnan, Liu Hongbo, Qiu Chengxiang, Vitale Steven, Miao Zhen, Seasock Matthew J, Palmer Matthew, Shin Myung K, Duffin Kevin L, Pullen Steven S, Edwards Todd L, Hellwege Jacklyn N, Hung Adriana M, Li Mingyao, Voight Benjamin F, Coffman Thomas M, Brown Christopher D, Susztak Katalin
Abstract excerpt
The functional interpretation of genome-wide association studies (GWAS) is challenging due to the cell-type-dependent influences of genetic variants. Here, we generated comprehensive maps of expression quantitative trait loci (eQTLs) for 659 microdissected human kidney samples and identified cell-type-eQTLs by mapping interactions between cell type abundances and genotypes. By partitioning heritability using...
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