Article

Leveraging three-dimensional chromatin architecture for effective reconstruction of enhancer-target gene regulatory network

2021-03-01

Abstract excerpt

<h4>ABSTRACT</h4> A growing amount of evidence in literature suggests that germline sequence variants and somatic mutations in non-coding distal regulatory elements may be crucial for defining disease risk and prognostic stratification of patients, in genetic disorders as well as in cancer. Their functional interpretation is challenging because genome-wide enhancer-target gene (ETG) pairing is an open problem in...

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Literature Corpus work: bc0c288c-b501-5228-a781-3a467500bda0
DOI: 10.1101/2021.03.01.432687

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