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Mouse models of Alzheimer's disease: The long and filamentous road

1 Sept 2003

Abstract excerpt

Alzheimer's disease (AD) is characterized by memory impairment leading to dementia, deposition of amyloid plaques and neurofibrillary tangles (NFTs), and neuronal loss. The major component of plaques is the amyloid beta peptide, A beta, whereas NFTs contain hyperphosphorylated forms of the microtubule-associated protein tau (tau). Familial AD (FAD) mutations either elevate A beta synthesis by favoring 'secretase'...

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PMID: 14503012
DOI: 10.1179/016164103101202020

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