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Rodent models for Alzheimer’s disease drug discovery

30 Apr 2015

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and personality changes, leading to dementia. Histopathological hallmarks are represented by aggregates of beta-amyloid peptide (Aβ) in senile plaques and deposition of hyperphosphorylated tau protein in neurofibrillary tangles in the brain. Rare forms of early onset familial Alzheimer's disease are due to gene...

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PMID: 25927677
DOI: 10.1517/17460441.2015.1041913

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