Comparative genomics of white and opaque cell states supports an epigenetic mechanism of phenotypic switching in Candida albicans.

doi:10.1093/g3journal/jkab001

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Article

Comparative genomics of white and opaque cell states supports an epigenetic mechanism of phenotypic switching in Candida albicans.

G3 (Bethesda, Md.) - 9 Feb 2021

Beekman Chapman N, Cuomo Christina A, Bennett Richard J, Ene Iuliana V

Abstract excerpt

Several Candida species can undergo a heritable and reversible transition from a 'white' state to a mating proficient 'opaque' state. This ability relies on highly interconnected transcriptional networks that control cell-type-specific gene expression programs over multiple generations. Candida albicans, the most prominent pathogenic Candida species, provides a well-studied paradigm for the white-opaque...

Topics

Candida albicans
Epigenesis, Genetic
Fungal Proteins
Gene Expression Regulation, Fungal
Gene Regulatory Networks
Genomics
Phenotype

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Identifiers

PMID: 33585874
DOI: 10.1093/g3journal/jkab001
PMCID: PMC8366294

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