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Article

Identification and Characterization of Wor4, a New Transcriptional Regulator of White-Opaque Switching.

G3 (Bethesda, Md.) - 15 Jan 2016

Lohse Matthew B, Johnson Alexander D

Abstract excerpt

The human fungal pathogen Candida albicans can switch between two cell types, "white" and "opaque," each of which is heritable through many cell divisions. Switching between these two cell types is regulated by six transcriptional regulators that form a highly interconnected circuit with multiple feedback loops. Here, we identify a seventh regulator of white-opaque switching, which we have named Wor4. We show...

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Identifiers

PMID: 26772749
DOI: 10.1534/g3.115.024885
PMCID: PMC4777133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and Characterization of Wor4, a New Transcriptional Regulator of White-Opaque Switching.PMID 26772749Read ↗

Structure of the transcriptional network controlling white-opaque switching in Candida albicans.Semantic proximity Read ↗

Interlocking Transcriptional Feedback Loops Control White-Opaque Switching in Candida albicansSemantic proximity Read ↗

Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domainsSemantic proximity Read ↗

Ssn6 Defines a New Level of Regulation of White-Opaque Switching in Candida albicans and Is Required For the Stochasticity of the SwitchSemantic proximity Read ↗

Comparative genomics of white and opaque cell states supports an epigenetic mechanism of phenotypic switching in Candida albicans.Semantic proximity Read ↗

Temporal anatomy of an epigenetic switch in cell programming: the white‐opaque transition of C. albicansSemantic proximity Read ↗

Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicans.Semantic proximity Read ↗

A Set of Diverse Genes Influence the Frequency of White-Opaque Switching in Candida albicans.Semantic proximity Read ↗

Epigenetic properties of white–opaque switching in <i>Candida albicans</i> are based on a self-sustaining transcriptional feedback loopSemantic proximity Read ↗

Regulation of white-opaque switching in Candida albicans.Semantic proximity Read ↗

Transcriptional control of C. albicans white-opaque switching and modulation by environmental cues and strain background.Semantic proximity Read ↗

Crystal structure of the WOPR-DNA complex and implications for Wor1 function in white-opaque switching of Candida albicans.Semantic proximity Read ↗

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