Transcriptional control of C. albicans white-opaque switching and modulation by environmental cues and strain background.

doi:10.1128/mbio.00581-25

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Article

Transcriptional control of C. albicans white-opaque switching and modulation by environmental cues and strain background.

mBio - 14 May 2025

Sharma Anupam, Homayoon Ameen, Weyler Michael, Frazer Corey, Ramírez-Zavala Bernardo, Morschhäuser Joachim, Bennett Richard J

Abstract excerpt

The opportunistic fungal pathogen Candida albicans can undergo cellular transitions in response to environmental cues that impact its lifestyle and its interactions with the human host. This is exemplified by the white-opaque switch, which is a heritable transition between two phenotypic states that is regulated by a highly interconnected network of transcription factors (TFs). To obtain greater understanding of...

Topics

Candida albicans
Gene Expression Regulation, Fungal
Transcription Factors
Transcription, Genetic
Fungal Proteins
Culture Media
Phenotype
Hydrogen-Ion Concentration

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PMID: 40202334
DOI: 10.1128/mbio.00581-25
PMCID: PMC12077150

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