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Trans-ancestry, Bayesian meta-analysis discovers 20 novel risk loci for inflammatory bowel disease in an African American, East Asian and European cohort.

Human molecular genetics - 19 Feb 2023

Cordero Roberto Y, Cordero Jennifer B, Stiemke Andrew B, Datta Lisa W, Buyske Steven, Kugathasan Subra, McGovern Dermot P B, Brant Steven R, Simpson Claire L

Abstract excerpt

Inflammatory bowel disease (IBD) is an immune-mediated chronic intestinal disorder with major phenotypes: ulcerative colitis (UC) and Crohn's disease (CD). Multiple studies have identified over 240 IBD susceptibility loci. However, most studies have centered on European (EUR) and East Asian (EAS) populations. The prevalence of IBD in non-EUR, including African Americans (AAs), has risen in recent years. Here we...

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PMID: 36308435
DOI: 10.1093/hmg/ddac269
PMCID: PMC9941836

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