Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn's disease in Asians.

doi:10.1093/hmg/ddy285

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Article

Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn's disease in Asians.

Human molecular genetics - 15 Nov 2018

Han Buhm, Akiyama Masato, Kim Kyung-Kon, Oh Hyunjung, Choi Hyunchul, Lee Cue Hyunkyu, Jung Seulgi, Lee Ho-Su, Kim Emma E, Cook Seungho, Haritunians Talin, Yamazaki Keiko, Park Sang Hyoung, Ye Byong Duk, McGovern Dermot P B, Esaki Motohiro, Kawaguchi Takaaki, Khor Seik-Soon, Taylor Kent D, Rotter Jerome I, Suzuki Yasuo, Matsui Toshiyuki, Motoya Satoshi, Bang So-Young, Kim Tae-Hwan, Momozawa Yukihide, Kamatani Yoichiro, Tokunaga Katsushi, Kubo Michiaki, Okada Yukinori, Yang Suk-Kyun, Song Kyuyoung

Abstract excerpt

Crohn's disease (CD) and ulcerative colitis (UC) are the major types of chronic inflammatory bowel disease (IBD) characterized by recurring episodes of inflammation of the gastrointestinal tract. Although it is well established that human leukocyte antigen (HLA) is a major risk factor for IBD, it is yet to be determined which HLA alleles or amino acids drive the risks of CD and UC in Asians. To define the roles...

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PMID: 30084967
DOI: 10.1093/hmg/ddy285

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