Article
HLA-DRB1*01:03 in patients with inflammatory bowel disease: a genotype-phenotype association study.
The lancet. Gastroenterology & hepatology - 1 Aug 2026
Zhang Qian, Shakweh Eathar, Sharip Mohmmed Tauseef, Zare Benjamin, Roberts Christopher, Wyatt Nicola J, Clough Jennifer, Bewshea Claire, Garwany Omar El, Lees Robert, Mukhtar Saima, Rehman Hameed, Thistle Hollie, Mulligan Robert, Taylor Melanie, Raymode Parizade, Hamilton Benjamin, Noor Nurulamin M, Morda Francesco, Taylor Madeleine, Gyanwali Mina, Tobi Ogwa, Kateroglou Stefanos, Von Hagt Sean, Sebastian Shaji, Hart Ailsa, Keylock Laura, Pele Laetitia, Lees Charlie W, Raine Tim, Lamb Christopher A, Anderson Carl A, Ahmad Tariq, Uhlig Holm, Parkes Miles, Fachal Laura, Kennedy Nicholas A, Lee James C
Abstract excerpt
BACKGROUND: The association between HLA-DRB1*01:03 and severe ulcerative colitis has long been recognised. However, the recent discovery of an association with neutralising auto-antibodies against IL-10 raises new questions about whether this haplotype contributes to other subphenotypes of inflammatory bowel disease (IBD). We sought to systematically reappraise the contribution of HLA-DRB1*01:03 across the full...
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