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Investigating the genetic makeup of the major histocompatibility complex (MHC) in the United Arab Emirates population through next-generation sequencing.

Scientific reports - 9 Feb 2024

Marzouka Nour Al Dain, Alnaqbi Halima, Al-Aamri Amira, Tay Guan, Alsafar Habiba

Abstract excerpt

The Human leukocyte antigen (HLA) molecules are central to immune response and have associations with the phenotypes of various diseases and induced drug toxicity. Further, the role of HLA molecules in presenting antigens significantly affects the transplantation outcome. The objective of this study was to examine the extent of the diversity of HLA alleles in the population of the United Arab Emirates (UAE) using...

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Identifiers

PMID: 38337023
DOI: 10.1038/s41598-024-53986-1
PMCID: PMC10858242

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