Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

doi:10.1038/ng.3359

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Article

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

Nature genetics - 1 Sept 2015

Liu Jimmy Z, van Sommeren Suzanne, Huang Hailiang, Ng Siew C, Alberts Rudi, Takahashi Atsushi, Ripke Stephan, Lee James C, Jostins Luke, Shah Tejas, Abedian Shifteh, Cheon Jae Hee, Cho Judy, Dayani Naser E, Franke Lude, Fuyuno Yuta, Hart Ailsa, Juyal Ramesh C, Juyal Garima, Kim Won Ho, Morris Andrew P, Poustchi Hossein, Newman William G, Midha Vandana, Orchard Timothy R, Vahedi Homayon, Sood Ajit, Sung Joseph Y, Malekzadeh Reza, Westra Harm-Jan, Yamazaki Keiko, Yang Suk-Kyun, Barrett Jeffrey C, Alizadeh Behrooz Z, Parkes Miles, Bk Thelma, Daly Mark J, Kubo Michiaki, Anderson Carl A, Weersma Rinse K

Abstract excerpt

Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease (IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or Immunochip genotype data from an extended cohort of 86,640 European individuals and Immunochip data from 9,846 individuals of East Asian, Indian or Iranian descent. We implicate 38 loci in IBD risk for the first time. For the...

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PMID: 26192919
DOI: 10.1038/ng.3359
PMCID: PMC4881818

Genes

IRGM
NOD2
TNFSF15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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