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Article

NK/T cell ratios associate with interleukin-2 receptor alpha chain expression and shedding in multiple sclerosis.

Journal of neuroimmunology - 15 Apr 2021

Mimpen Max, Rolf Linda, Muris Anne-Hilde, Gerlach Oliver, Poelmans Geert, Hupperts Raymond, Smolders Joost, Damoiseaux Jan

Abstract excerpt

NK/T-cell ratios predict disease activity in relapsing remitting multiple sclerosis (RRMS). We investigated in 50 RRMS patients whether interleukin-2 receptor alpha-chain (IL-2Rα) expression and shedding associates with NK/T-cell balance, as suggested by daclizumab-trials in RRMS. A subsample (N = 31) was genotyped for IL2RA-associated MS risk SNPs. CD56bright NK-cell/IL-17A+CD4+ T-cell ratios correlated...

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Share to CD4-Positive T-Lymphocytes
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interleukin-2 Receptor alpha Subunit

Share to Killer Cells, Natural

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Share to Multiple Sclerosis, Relapsing-Remitting

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 33529846
DOI: 10.1016/j.jneuroim.2021.577499

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