The IL-7Rα pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis.

doi:10.4049/jimmunol.1102559

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The IL-7Rα pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2012

Kreft Karim L, Verbraak Evert, Wierenga-Wolf Annet F, van Meurs Marjan, Oostra Ben A, Laman Jon D, Hintzen Rogier Q

Abstract excerpt

The IL-7Rα single nucleotide polymorphism rs6897932 is associated with an increased risk for multiple sclerosis (MS). IL-7Rα is a promising candidate to be involved in autoimmunity, because it regulates T cell homeostasis, proliferation, and antiapoptotic signaling. However, the exact underlying mechanisms in the pathogenesis of MS are poorly understood. We investigated whether CD4 and CD8 lymphocyte subsets...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to STAT5 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

Share to CD8-Positive T-Lymphocytes

Share to Granzymes

Share to Interleukin-7

Share to Membrane Proteins

Share to Multiple Sclerosis

Share to Receptors, Interleukin-7

Source

Open in PubMed

Identifiers

PMID: 22262655
DOI: 10.4049/jimmunol.1102559

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The IL-7Rα pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis.PMID 22262655Read ↗

The interleukin-7 receptor α chain contributes to altered homeostasis of regulatory T cells in multiple sclerosis.Semantic proximity Read ↗

Decreased systemic IL-7 and soluble IL-7Rα in multiple sclerosis patients.Semantic proximity Read ↗

IL7Rα contributes to experimental autoimmune encephalomyelitis through altered T cell responses and nonhematopoietic cell lineages.Semantic proximity Read ↗

IL7RA haplotype-associated alterations in cellular immune function and gene expression patterns in multiple sclerosis.Semantic proximity Read ↗

IL-7Rα confers susceptibility to experimental autoimmune encephalomyelitis.Semantic proximity Read ↗

Interleukin 7 Receptor Alpha Gene Variants Are Correlated with Gene Expression in Patients with Relapsing-remitting Multiple Sclerosis.Semantic proximity Read ↗

Interleukin 7 receptor polymorphisms and the risk of multiple sclerosis: A meta-analysis.Semantic proximity Read ↗

Genetic variants in interleukin 7 receptor α chain (IL-7Ra) are associated with multiple sclerosis risk and disability progression in Central European Slovak population.Semantic proximity Read ↗

Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.Semantic proximity Read ↗

IL7RA genetic variants differentially affect IL-7Rα expression and alternative splicing: a role in autoimmune and infectious diseases?Semantic proximity Read ↗

CD8<sup>+</sup>T cells in multiple sclerosisSemantic proximity Read ↗

APOE ε4–associated downregulation of the IL‐7/IL‐7R pathway in effector memory T cells: Implications for Alzheimer's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.