IL2RA Methylation and Gene Expression in Relation to the Multiple Sclerosis-Associated Gene Variant rs2104286 and Soluble IL-2Rα in CD8+ T Cells.

doi:10.3389/fimmu.2021.676141

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Article

IL2RA Methylation and Gene Expression in Relation to the Multiple Sclerosis-Associated Gene Variant rs2104286 and Soluble IL-2Rα in CD8+ T Cells.

Frontiers in immunology - 1 Jan 2021

Buhelt Sophie, Laigaard Hannah-Marie, von Essen Marina Rode, Ullum Henrik, Oturai Annette, Sellebjerg Finn, Søndergaard Helle Bach

Abstract excerpt

CD8+ T cells are involved in the pathogenesis of multiple sclerosis (MS). The interleukin-2 receptor α (IL-2Rα) is important for CD8+ T cell function, and single nucleotide polymorphisms (SNPs) in the IL2RA gene encoding IL-2Rα increase the risk of MS. Therefore, in isolated CD8+ T cells we investigated IL2RA gene methylation and gene expression in relation to the MS-associated IL2RA SNP rs2104286 and soluble...

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PMID: 34386002
DOI: 10.3389/fimmu.2021.676141
PMCID: PMC8353370

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