Decreased systemic IL-7 and soluble IL-7Rα in multiple sclerosis patients.

doi:10.1038/gene.2012.34

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Article

Decreased systemic IL-7 and soluble IL-7Rα in multiple sclerosis patients.

Genes and immunity - 1 Oct 2012

Kreft K L, Verbraak E, Wierenga-Wolf A F, van Meurs M, Oostra B A, Laman J D, Hintzen R Q

Abstract excerpt

Polymorphisms (single-nucleotide polymorphism (SNP)) in the interleukin-7 receptor-α (IL-7Rα)/IL-7 pathway are associated with an increased risk to develop multiple sclerosis (MS). The rs6897932 SNP in the IL-7Rα leads to increased soluble IL-7Rα production. Given the functional interaction between sIL-7Rα, membrane-bound IL-7Rα and IL-7, we assessed IL-7, mIL-7Rα and sIL-7Rα levels in MS patients and healthy...

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PMID: 22914435
DOI: 10.1038/gene.2012.34

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