Article
Multiple sclerosis treatment effects on plasma cytokine receptor levels.
Clinical immunology (Orlando, Fla.) - 1 Feb 2018
Bedri Sahl Khalid, Fink Katharina, Manouchehrinia Ali, Lundström Wangko, Kockum Ingrid, Olsson Tomas, Hillert Jan, Glaser Anna
Abstract excerpt
Genetic variants within some cytokine receptor genes have been associated with MS susceptibility, including IL7RA and IL2RA. As these genes are expressed by cells targeted by immune-modulatory drugs, we explored the potential role of their gene products as biomarkers in monitoring MS treatment. We assessed the impact of natalizumab followed by fingolimod on the intra-individual changes of plasma protein levels of...
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