Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2010

Hoe Edwin, McKay Fiona C, Schibeci Stephen D, Gandhi Kaushal, Heard Rob N, Stewart Graeme J, Booth David R

Abstract excerpt

Common genetic variants of IL-7 receptor alpha (IL-7Ralpha) have recently been shown to affect susceptibility to multiple sclerosis (MS) and type 1 diabetes, and survival following bone marrow transplantation. Transcription of the gene produces two dominant isoforms, with or without exon 6, which code for membrane-bound or soluble IL-7Ralpha, respectively. The haplotypes produce different isoform ratios. We have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dendritic Cells
Share to Interleukin-17

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiple Sclerosis

Share to Receptors, Interleukin-7

Share to T-Lymphocytes, Helper-Inducer

Share to Th1 Cells

Share to Th2 Cells

Share to Thymic Stromal Lymphopoietin

Source

Identifiers

PMID: 20097866
DOI: 10.4049/jimmunol.0902900

Genes

TSLP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells.PMID 20097866Read ↗

IL7RA haplotype-associated alterations in cellular immune function and gene expression patterns in multiple sclerosis.Semantic proximity Read ↗

Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis.Semantic proximity Read ↗

Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.Semantic proximity Read ↗

Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Ralpha) in peripheral blood from patients with multiple sclerosis (MS).Semantic proximity Read ↗

Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis.Semantic proximity Read ↗

IL7RA genetic variants differentially affect IL-7Rα expression and alternative splicing: a role in autoimmune and infectious diseases?Semantic proximity Read ↗

Interleukin-7 receptor alpha (IL-7Ralpha) deficiency: cellular and molecular bases. Analysis of clinical, immunological, and molecular features in 16 novel patients.Semantic proximity Read ↗

Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-alpha gene and their associations with multiple sclerosis.Semantic proximity Read ↗

Context-specific regulation of monocyte surface IL7R expression and soluble receptor secretion by a common autoimmune risk alleleSemantic proximity Read ↗

The interleukin-7 receptor α chain contributes to altered homeostasis of regulatory T cells in multiple sclerosis.Semantic proximity Read ↗

Interleukin-7 receptor α-chain haplotypes differentially affect soluble IL-7 receptor and IL-7 serum concentrations in children with type 1 diabetes.Semantic proximity Read ↗

Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk alleleSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.