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Article

The interleukin-7 receptor α chain contributes to altered homeostasis of regulatory T cells in multiple sclerosis.

European journal of immunology - 1 Mar 2011

Haas Jürgen, Korporal Mirjam, Schwarz Alexander, Balint Bettina, Wildemann Brigitte

Abstract excerpt

Treg homeostasis is disturbed in multiple sclerosis (MS). Frequencies of recent thymic emigrant (RTE)-Treg are reduced and the disparity between RTE-Treg and long-lived memory Treg coincides with the MS-associated Treg defect, as shown previously. Recent studies demonstrate that IL-7 and thymic stromal lymphopoietin (TSLP) are critical for Treg maturation. Therefore, altered signaling through their receptors...

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Source

Identifiers

PMID: 21287555
DOI: 10.1002/eji.201041139

Genes

TSLP

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