Article
Genetic variation in PBMC-produced IFN-γ and TNF-α associations with relapse in multiple sclerosis.
Journal of the neurological sciences - 15 Feb 2015
Zhou Yuan, Taylor Bruce, van der Mei Ingrid, Stewart Niall, Charlesworth Jac, Blizzard Leigh, Ponsonby Anne-Louise, Dwyer Terence, Pittas Fotini, Simpson Steve
Abstract excerpt
BACKGROUND: Alterations in peripheral blood mononuclear cell (PBMC) cytokine production have been found in multiple sclerosis (MS) compared to healthy controls. We have previously found that stimulated PBMC-produced TNF-α and IFN-γ modulated MS relapse risk, such that raised TNF-α was protective, while raised IFN-γ increased relapse risk. OBJECTIVE: To assess whether SNPs within genes for relevant cytokines and...
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