Article
Biomarkers of systemic inflammation, soluble IL-2Rα and the multiple sclerosis-associated IL2RA SNP rs2104286 in healthy subjects and multiple sclerosis patients.
Multiple sclerosis and related disorders - 1 Sept 2021
Buhelt Sophie, Søndergaard Helle Bach, Mahler Mie Reith, Cobanovic Stefan, Börnsen Lars, Ammitzbøll Cecilie, Oturai Annette Bang, Sellebjerg Finn
Abstract excerpt
Soluble interleukin-2 (IL-2) receptor α (sIL-2Rα) antagonizes IL-2 signaling and is involved in the pathogenesis of several immune-mediated diseases including multiple sclerosis (MS). The level of sIL-2Rα is affected by the MS-associated single nucleotide polymorphism (SNP) rs2104286. By use of ELISA and electrochemiluminescence, we investigated if 26 biomarkers of systemic inflammation were associated with...
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