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Article

Fission Yeast Methylenetetrahydrofolate Reductase Ensures Mitotic and Meiotic Chromosome Segregation Fidelity.

International journal of molecular sciences - 11 Jan 2021

Lim Kim Kiat, Teo Hwei Yee, Tan Yuan Yee, Zeng Yi Bing, Lam Ulysses Tsz Fung, Choolani Mahesh, Chen Ee Sin

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the folate metabolic pathway, and its loss of function through polymorphisms is often associated with human conditions, including cancer, congenital heart disease, and Down syndrome. MTHFR is also required in the maintenance of heterochromatin, a crucial determinant of genomic stability and precise chromosomal segregation. Here, we characterize the...

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Identifiers

PMID: 33440639
DOI: 10.3390/ijms22020639
PMCID: PMC7827777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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