Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions.

Nature cell biology - 1 Apr 2005

Torres-Rosell Jordi, Machín Félix, Farmer Sarah, Jarmuz Adam, Eydmann Trevor, Dalgaard Jacob Z, Aragón Luis

Abstract excerpt

Structure chromosome (SMC) proteins organize the core of cohesin, condensin and Smc5-Smc6 complexes. The Smc5-Smc6 complex is required for DNA repair, as well as having another essential but enigmatic function. Here, we generated conditional mutants of SMC5 and SMC6 in budding yeast, in which the essential function was affected. We show that mutant smc5-6 and smc6-9 cells undergo an aberrant mitosis in which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Chromatin
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Segregation

Share to Chromosomes

Share to Cohesins

Share to DNA, Ribosomal

Share to Repetitive Sequences, Nucleic Acid

Source

Identifiers

PMID: 15793567
DOI: 10.1038/ncb1239

Genes

SMC5
SMC6
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions.PMID 15793567Read ↗

Smc5-Smc6 complex preserves nucleolar integrity in S. cerevisiae.Semantic proximity Read ↗

Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites.Semantic proximity Read ↗

Smc5/6 maintains stalled replication forks in a recombination-competent conformation.Semantic proximity Read ↗

Smc5/6 is required for repair at collapsed replication forks.Semantic proximity Read ↗

Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair.Semantic proximity Read ↗

Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function.Semantic proximity Read ↗

Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.Semantic proximity Read ↗

Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE.Semantic proximity Read ↗

SMC5 and MMS21 are required for chromosome cohesion and mitotic progression.Semantic proximity Read ↗

SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family.Semantic proximity Read ↗

SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.