Article
SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication.
Molecular cell - 6 Apr 2017
Taneja Nitika, Zofall Martin, Balachandran Vanivilasini, Thillainadesan Gobi, Sugiyama Tomoyasu, Wheeler David, Zhou Ming, Grewal Shiv I S
Abstract excerpt
Heterochromatin can be epigenetically inherited in cis, leading to stable gene silencing. However, the mechanisms underlying heterochromatin inheritance remain unclear. Here, we identify Fft3, a fission yeast homolog of the mammalian SMARCAD1 SNF2 chromatin remodeler, as a factor uniquely required for heterochromatin inheritance, rather than for de novo assembly. Importantly, we find that Fft3 suppresses turnover...
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