Article
H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.
PLoS genetics - 6 Jan 2011
Hansen Klavs R, Hazan Idit, Shanker Sreenath, Watt Stephen, Verhein-Hansen Janne, Bähler Jürg, Martienssen Robert A, Partridge Janet F, Cohen Amikam, Thon Geneviève
Abstract excerpt
Nucleosomes in heterochromatic regions bear histone modifications that distinguish them from euchromatic nucleosomes. Among those, histone H3 lysine 9 methylation (H3K9me) and hypoacetylation have been evolutionarily conserved and are found in both multicellular eukaryotes and single-cell model organisms such as fission yeast. In spite of numerous studies, the relative contributions of the various heterochromatic...
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