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Article

Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy.

Nature - 2 Mar 2017

Folco H Diego, Chalamcharla Venkata R, Sugiyama Tomoyasu, Thillainadesan Gobi, Zofall Martin, Balachandran Vanivilasini, Dhakshnamoorthy Jothy, Mizuguchi Takeshi, Grewal Shiv I S

Abstract excerpt

Uniparental disomy (UPD), in which an individual contains a pair of homologous chromosomes originating from only one parent, is a frequent phenomenon that is linked to congenital disorders and various cancers. UPD is thought to result mostly from pre- or post-zygotic chromosome missegregation. However, the factors that drive UPD remain unknown. Here we use the fission yeast Schizosaccharomyces pombe as a model to...

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PMID: 28199302
DOI: 10.1038/nature21372
PMCID: PMC5567995

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