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Folic acid and sperm quality improvement: insights from snRNA sequencing and RNA splicing mechanisms

29 Aug 2025

Abstract excerpt

Folic acid, an essential micronutrient in male reproductive physiology, serves as a critical cofactor in one-carbon metabolism by facilitating nucleotide biosynthesis and epigenetic methylation processes fundamental to spermatogenesis. Its metabolic role is characterized by two pivotal biochemical transformations: the remethylation of homocysteine to methionine and the subsequent generation of...

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PMID: 40948861
DOI: 10.3389/fnut.2025.1648307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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