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Genetic variants in TNFA, LTA, TLR2 and TLR4 genes and risk of sepsis in patients with severe trauma: nested case-control study in a level-1 trauma centre in SERBIA.

Injury - 1 Mar 2021

Djuric Olivera, Andjelkovic Marina, Vreca Misa, Skakic Anita, Pavlovic Sonja, Novakovic Ivana, Jovanovic Bojan, Skodric-Trifunovic Vesna, Markovic-Denic Ljiljana

Abstract excerpt

INTRODUCTION: Single nucleotide variants (SNVs) represent important genetic risk factors for susceptibility to posttraumatic sepsis and a potential target for immunotherapy. We aimed to evaluate the association between 8 different SNVs within tumor necrosis factor alpha (TNFA), lymphotoxin alpha (LTA) and Toll-like receptor (TLR2 and TLR4) genes and the risk of posttraumatic sepsis. METHODS: Nested case-control...

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Identifiers

PMID: 33436266
DOI: 10.1016/j.injury.2020.12.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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