Article
Sepsis syndrome and death in trauma patients are associated with variation in the gene encoding tumor necrosis factor.
Critical care medicine - 1 May 2008
Menges Thilo, König Inke R, Hossain Hamid, Little Simon, Tchatalbachev Svetlin, Thierer Felix, Hackstein Holger, Franjkovic Isolda, Colaris Thorsten, Martens Florian, Weismüller Katja, Langefeld Tanja, Stricker Jürgen, Hempelmann Gunter, Vos Pieter E, Ziegler Andreas, Jacobs Bram, Chakraborty Trinad, Bein Gregor
Abstract excerpt
OBJECTIVE: Patients encountering severe trauma are at risk of developing sepsis syndrome and subsequent multiple organ failure. This is often associated with fatal outcome despite survival of the initial injury. We postulate that variation of the gene coding for tumor necrosis factor (TNF)-alpha is associated with increased occurrence of sepsis syndrome and mortality in trauma patients. DESIGN: Prospective cohort...
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