Article
Rs1800625 in the receptor for advanced glycation end products gene predisposes to sepsis and multiple organ dysfunction syndrome in patients with major trauma.
Critical care (London, England) - 9 Jan 2015
Zeng Ling, Du Juan, Gu Wei, Zhang An-qiang, Wang Hai-yan, Wen Da-lin, Qiu Lin, Yang Xue-tao, Sun Jian-hui, Zhang Mao, Hao Jiang, Jiang Jian-xin
Abstract excerpt
INTRODUCTION: The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, it plays pivotal roles in the pathogenesis of sepsis in several ways. Our previous study showed that rs1800625 (-429T/C) revealed a strong clinical relevance with sepsis morbidity rate and multiple organ dysfunction syndrome (MODS) in patients with major trauma. In this study, we...
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