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Article

Variation in the TLR4 gene influences the risk of organ failure and shock posttrauma: a cohort study.

The Journal of trauma - 1 Jan 2009

Shalhub Sherene, Junker Christopher E, Imahara Scott D, Mindrinos Michael N, Dissanaike Sharmila, O'Keefe Grant E

Abstract excerpt

BACKGROUND: Genetic variation contributes to risk and outcomes of sepsis. We sought to determine whether variation in inflammation related genes is associated with severity of sepsis in trauma patients. METHODS: A cohort of severely injured Caucasian patients was studied and genotyped for candidate single nucleotide polymorphisms (SNPs). These were toll-like receptor 4 (TLR4) A896G, tumor necrosis factor-alpha...

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Source

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Identifiers

PMID: 19131814
DOI: 10.1097/TA.0b013e3181938d50
PMCID: PMC2740632

Genes

TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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