Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The G-->A single nucleotide polymorphism at the -308 position in the tumor necrosis factor-alpha promoter increases the risk for severe sepsis after trauma.

The Journal of trauma - 1 May 2002

O'Keefe Grant E, Hybki Dixie L, Munford Robert S

Abstract excerpt

BACKGROUND: Clinical factors do not adequately explain why some patients develop severe sepsis after trauma and why others do not. We sought to determine whether genetic factors contribute to this risk. METHODS: Patients admitted to a single Level I trauma center were enrolled and DNA was isolated from leukocytes. The risk for severe sepsis and for death associated with polymorphism in the tumor necrosis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Frequency
Share to Odds Ratio
Share to Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Risk Factors

Share to Sepsis

Share to Tumor Necrosis Factor-alpha

Share to Wounds and Injuries

Source

Identifiers

PMID: 11988644
DOI: 10.1097/00005373-200205000-00001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The G-->A single nucleotide polymorphism at the -308 position in the tumor necrosis factor-alpha promoter increases the risk for severe sepsis after trauma.PMID 11988644Read ↗

Sepsis syndrome and death in trauma patients are associated with variation in the gene encoding tumor necrosis factor.Semantic proximity Read ↗

Genetic variants in TNFA, LTA, TLR2 and TLR4 genes and risk of sepsis in patients with severe trauma: nested case-control study in a level-1 trauma centre in SERBIA.Semantic proximity Read ↗

The TNF-α (-238 G/A) polymorphism could protect against development of severe sepsis.Semantic proximity Read ↗

Tumor necrosis factor alpha gene polymorphism is associated with the outcome of trauma patients in Chinese Han population.Semantic proximity Read ↗

Characterization of tumour necrosis factor-alpha genetic variants and mRNA expression in patients with severe sepsis.Semantic proximity Read ↗

Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression.Semantic proximity Read ↗

Tumor necrosis factor gene polymorphisms, leukocyte function, and sepsis susceptibility in blunt trauma patients.Semantic proximity Read ↗

Does tumor necrosis factor alpha promoter -308 A/G polymorphism has any role in the susceptibility to sepsis and sepsis risk? A meta-analysis.Semantic proximity Read ↗

Role of Tumour Necrosis Factor-Alpha promoter 308A/G polymorphism in sepsis and sepsis mortality: A Meta-AnalysisSemantic proximity Read ↗

Genetic variation in the TNF gene is associated with susceptibility to severe sepsis, but not with mortality.Semantic proximity Read ↗

Tumor necrosis factor gene polymorphism results in high TNF level in sepsis and septic shock.Semantic proximity Read ↗

Association between tumor necrosis factor-alpha promoter -308 A/G polymorphism and susceptibility to sepsis and sepsis mortality: a systematic review and meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.