Article
Polymorphisms in the toll-like receptor 9 gene associated with sepsis and multiple organ dysfunction after major blunt trauma.
The British journal of surgery - 1 Sept 2011
Chen K-H, Zeng L, Gu W, Zhou J, Du D-Y, Jiang J-X
Abstract excerpt
BACKGROUND: Toll-like receptor (TLR) 9 is the pattern recognition receptor for microbial DNA. Genetic variation within pattern recognition receptors for bacterial endotoxin and exotoxin has been shown to be associated with the risk of sepsis and organ dysfunction in critical illness. However, little is known about the clinical relevance of TLR9 gene polymorphisms in critical illness. METHODS: A total of 557...
Topics
- Adult
- Aged
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Middle Aged
- Multiple Organ Failure
- Polymorphism, Single Nucleotide