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Article

Genetic variation in the TNF gene is associated with susceptibility to severe sepsis, but not with mortality.

PloS one - 1 Jan 2012

Song Zhenju, Song Yuanlin, Yin Jun, Shen Yao, Yao Chenling, Sun Zhan, Jiang Jinjun, Zhu Duming, Zhang Yong, Shen Qinjun, Gao Lei, Tong Chaoyang, Bai Chunxue

Abstract excerpt

BACKGROUND: Tumor necrosis factor (TNF) and TNF receptor superfamily (TNFR)-mediated immune response play an essential role in the pathogenesis of severe sepsis. Studies examining associations of TNF and lymphotoxin-α (LTA) single nucleotide polymorphisms (SNPs) with severe sepsis have produced conflicting results. The objective of this study was to investigate whether genetic variation in TNF, LTA, TNFRSF1A and...

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Source

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Identifiers

PMID: 23029405
DOI: 10.1371/journal.pone.0046113
PMCID: PMC3459853

Genes

TNF
LTA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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