Identification of haplotype tag single nucleotide polymorphisms within the nuclear factor-κB family genes and their clinical relevance in patients with major trauma.

doi:10.1186/s13054-015-0836-6

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Article

Identification of haplotype tag single nucleotide polymorphisms within the nuclear factor-κB family genes and their clinical relevance in patients with major trauma.

Critical care (London, England) - 20 Mar 2015

Pan Wei, Zhang An Qiang, Gu Wei, Gao Jun Wei, Du Ding Yuan, Zhang Lian Yang, Zeng Ling, Du Juan, Wang Hai Yan, Jiang Jian Xin

Abstract excerpt

INTRODUCTION: Nuclear factor-κB (NF-κB) family plays an important role in the development of sepsis in critically ill patients. Although several single nucleotide polymorphisms (SNPs) have been identified in the NF-κB family genes, only a few SNPs have been studied. METHODS: A total of 753 patients with major blunt trauma were included in this study. Tag SNPs (tSNPs) were selected from the NF-κB family genes...

Topics

Adolescent
Adult
Aged
Alleles
Asian People
China
Female
Gene Frequency
Genotype
Haplotypes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocytes, Mononuclear

Male

Middle Aged

Multiple Organ Failure

NF-kappa B

Polymorphism, Single Nucleotide

Prospective Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 25880845
DOI: 10.1186/s13054-015-0836-6
PMCID: PMC4404128

Genes

NFKB1
REL
RELA
TNF
NFKB2
RELB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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