Article
Effects of Sequence Variations in Innate Immune Response Genes on Infectious Outcome in Trauma Patients: A Comprehensive Review.
Shock (Augusta, Ga.) - 1 Nov 2015
Bronkhorst Maarten W G A, Patka Peter, Van Lieshout Esther M M
Abstract excerpt
Infectious complications, sepsis, and multiple organ dysfunction syndrome (MODS) remain important causes for morbidity and mortality in patients who survive the initial trauma. Increasing evidence suggests that genetic variants, particularly single nucleotide polymorphisms (SNPs), are critical determinants for interindividual differences in both inflammatory responses and clinical outcome in sepsis patients....
Topics
- Adaptor Proteins, Signal Transducing
- Cytokines
- Genetic Predisposition to Disease
- Humans
- Immunity, Innate
- Multiple Organ Failure
- Polymorphism, Single Nucleotide
- Receptors, Pattern Recognition
- Sepsis
- Wound Infection