Article
Overlapping mechanisms promote postsynaptic RAD-51 filament disassembly during meiotic double-strand break repair.
Molecular cell - 29 Jan 2010
Ward Jordan D, Muzzini Diego M, Petalcorin Mark I R, Martinez-Perez Enrique, Martin Julie S, Plevani Paolo, Cassata Giuseppe, Marini Federica, Boulton Simon J
Abstract excerpt
Homologous recombination (HR) is essential for repair of meiotic DNA double-strand breaks (DSBs). Although the mechanisms of RAD-51-DNA filament assembly and strand exchange are well characterized, the subsequent steps of HR are less well defined. Here, we describe a synthetic lethal interaction between the C. elegans helicase helq-1 and RAD-51 paralog rfs-1, which results in a block to meiotic DSB repair after...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.