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Article

Single-cell mutational profiling enhances the clinical evaluation of AML MRD.

Blood advances - 10 Mar 2020

Ediriwickrema Asiri, Aleshin Alexey, Reiter Johannes G, Corces M Ryan, Köhnke Thomas, Stafford Melissa, Liedtke Michaela, Medeiros Bruno C, Majeti Ravindra

Abstract excerpt

Although most patients with acute myeloid leukemia (AML) achieve clinical remission with induction chemotherapy, relapse rates remain high. Next-generation sequencing enables minimal/measurable residual disease (MRD) detection; however, clinical significance is limited due to difficulty differentiating between pre-leukemic clonal hematopoiesis and frankly malignant clones. Here, we investigated AML MRD using...

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Acute Myeloid Leukemia Research
Cancer Genomics and Diagnostics
Clonal Evolution
Leukemia, Myeloid, Acute
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm, Residual

Remission Induction

Single-cell and spatial transcriptomics

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Identifiers

PMID: 32150611
DOI: 10.1182/bloodadvances.2019001181
PMCID: PMC7065471

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