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Article

Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?

Disease models & mechanisms - 1 Aug 2014

Grove Carolyn S, Vassiliou George S

Abstract excerpt

Acute myeloid leukaemia (AML) is an uncontrolled clonal proliferation of abnormal myeloid progenitor cells in the bone marrow and blood. Advances in cancer genomics have revealed the spectrum of somatic mutations that give rise to human AML and drawn our attention to its molecular evolution and clonal architecture. It is now evident that most AML genomes harbour small numbers of mutations, which are acquired in a...

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Identifiers

PMID: 25056697
DOI: 10.1242/dmm.015974
PMCID: PMC4107323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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