Article
Clonal competition within complex evolutionary hierarchies shapes AML over time.
Nature communications - 5 Feb 2020
Sandén Carl, Lilljebjörn Henrik, Orsmark Pietras Christina, Henningsson Rasmus, Saba Karim H, Landberg Niklas, Thorsson Hanna, von Palffy Sofia, Peña-Martinez Pablo, Högberg Carl, Rissler Marianne, Gisselsson David, Lazarevic Vladimir, Juliusson Gunnar, Ågerstam Helena, Fioretos Thoas
Abstract excerpt
Clonal heterogeneity and evolution has major implications for disease progression and relapse in acute myeloid leukemia (AML). To model clonal dynamics in vivo, we serially transplanted 23 AML cases to immunodeficient mice and followed clonal composition for up to 15 months by whole-exome sequencing of 84 xenografts across two generations. We demonstrate vast changes in clonality that both progress and reverse...
Topics
- Adult
- Aged
- Aged, 80 and over
- Animals
- Clonal Evolution
- Disease Progression
- Female
- Humans
- Leukemia, Myeloid, Acute
- Male