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Article

Characterizing the effect of background selection on the polygenicity of brain-related traits.

Genomics - 1 Jan 2021

Wendt Frank R, Pathak Gita A, Overstreet Cassie, Tylee Daniel S, Gelernter Joel, Atkinson Elizabeth G, Polimanti Renato

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have demonstrated that psychopathology phenotypes are affected by many risk alleles with small effect (polygenicity). It is unclear how ubiquitously evolutionary pressures influence the genetic architecture of these traits. METHODS: We partitioned SNP heritability to assess the contribution of background (BGS) and positive selection, Neanderthal local ancestry,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 33278486
DOI: 10.1016/j.ygeno.2020.11.032
PMCID: PMC7855394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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