Article

The evolutionary genetics of polygenic diseases with the largest global burden in mortality rates

2021-12-14

Abstract excerpt

<h4>Background</h4> Although the prevalence of many complex diseases varies across human populations, the extent to which differences in the risks of common polygenic diseases are due to local adaptation is largely unknown. Focusing on the ten hereditary diseases with the largest global disease burden in terms of mortality rates, we leveraged GWAS findings from multiple ascertainment schemes to quantify collective...

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Literature Corpus work: 2d718cd8-01ac-56de-8002-f5af9f9bf967
DOI: 10.1101/2021.12.10.21267630

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