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Article

Genetic architectures of brain-related traits are shaped by strong selective constraints.

Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2026

Zhu Huisheng, Simons Yuval B, Spence Jeffrey P, Sella Guy, Pritchard Jonathan K

Abstract excerpt

Genome-wide association studies (GWAS) have identified hundreds of significant loci for psychiatric disorders, yet the strength of these associations remains modest compared to other human complex traits with similar numbers of hits. Whether this pattern reflects statistical artifacts or real biological differences-and, if the latter, what underlies it-remains unclear. In addition to psychiatric disorders, we...

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Topics

Humans
Genome-Wide Association Study
Brain
Selection, Genetic
Quantitative Trait Loci
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Models, Genetic

Gene Frequency

Phenotype

Mental Disorders

Source

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Identifiers

PMID: 42679042
DOI: 10.1073/pnas.2609814123
PMCID: PMC13552918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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